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550. 5.7.1 Unconfigured Sending Domain
Last Updated: Jan 25, 2017 06:26PM EST
Improperly Configured Sending Domain
If you receive the following error message "550 5.7.1 Unconfigured Sending Domain" as a response when sending a transmission, it is because you used a from address whose domain is not one of the sending domains that you created in your account.
If I use "email@example.com" as my message's from address, but the only sending domain in my account is autos.example.com, I will receive a 550 5.7.1 error message when I make a transmission with the REST API or SMTP relay.
Changing the from address to "firstname.lastname@example.org" will correct the error, because autos.example.com is a configured sending domain.
Refer to this Knowledge Base Article to learn more about how to configure Sending Domains.